Molecular Simulations of Ion Permeation in Potassium Channels
نویسندگان
چکیده
منابع مشابه
Molecular Simulations of Ion Permeation in Potassium Channels
specific steps in voltage-activation path of an ion channel are altered by a potent allosteric inhibitor. The Kþ channel peptide inhibitor guangxitoxin-1E (GxTX) is partial inverse agonist of the voltage gated potassium channel subtype Kv2.1 from rat. At saturating concentrations of GxTX, Kv2.1 requires higher voltages to activate. The GxTX modulated conductance requires more voltage to activat...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.11.898